Aptamers in most cases are themselves nucleic acids, generally used to target other bio-molecules. I wonder if we can design aptamers in such a way that they target other nucleic acids.
Will this increase specificity (owing to SELEX) as compared with normal hybridization based targetting/detection.
@Sanat
If nucleic acids are generated for any non-nucleic acid target, then it is called an aptamer. You can generate them using SELEX.
But if your target is a nucleic acid, then at that time you do not call them aptamer. You can call them hybridization probes or detection probes. You do not have to generate them using SELEX. You just need sequence of your target nucleic acid . Then you can design complementary sequence for that target sequence and use it as hybridization probe.
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