Have any of you done some research and could share something about Rb and p53 tumor suppressor genes and their mutations in cells?
Mutations in the Rb and p53 pathway account for ~80-90% defects in human cancers. Inactivation of these two tumor suppressors in human cells is sufficient for immortalization, thus allowing cells to proliferate indefinitely and acquire additional genetic alterations.
both are cell cycle checkers, p53 is often regarded as the "guardian of the genome"..
http://www.ncbi.nlm.nih.gov/pubmed/12204530
p53 gene known to be wild in some cancer cells where its expression will be influenced by STAT3 (also some other transcriptional factors). Binding of STAT3 on the DNA sequences prevents the binding of p53.As a result the p53 cannot do its function (like cell cycle regulation ,proliferation etc).
from the literature.....
some melanoma cancer cells has wild p53, some ovarian cancer cells has p53 mutations ( deleted mutations)
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