Dear friend Ashish Sriram Mishra

That's a very interesting question. Based on my web search, it seems that guar gum and modified citrus pectin can be used together to formulate nanoparticles for colon targeted drug delivery. According to one study (Pectine Polymers...), guar gum and pectin can enhance the colon targeting of solid self-nanoemulsifying drug delivery systems (SNEDDS) by protecting the active molecules from the acidic environment of the stomach and small intestine and by being degraded by the colonic microflora (pharmaceutical and drug...). Another study (guar gum- an over...) reported that pectin polymers have various advantages for colon-targeted antitumor drug delivery, such as biocompatibility, biodegradability, nontoxicity, and controlled release properties. Pectin can also inhibit tumor growth and reduce metastasis rate by itself (guar gum-an...). Therefore, it seems that guar gum and modified citrus pectin can be a promising combination for colon targeted drug delivery of nanoparticles.

Source:

(1) Development of Guar Gum-Pectin-Based Colon Targeted Solid Self .... https://www.mdpi.com/1999-4923/14/11/2384.

(2) Guar Gum - an overview | ScienceDirect Topics. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/guar-gum.

(3) Pectin polymers for colon-targeted antitumor drug delivery. https://www.sciencedirect.com/science/article/pii/S0141813020331470.

(4) Pharmaceutical and drug delivery applications of pectin and its .... https://www.sciencedirect.com/science/article/pii/S2405844022019429.

(5) Development of Guar Gum-Pectin-Based Colon Targeted Solid Self ... - PubMed. https://pubmed.ncbi.nlm.nih.gov/36365203/.