Both the systems are designated with BMSC, but can someone really tell me what is the difference between them?
Thanking You,
Regards,
Tarun
Hi Tarun. The stromal fraction from bone marrow includes a number of different, adherent, cell types such as fibroblasts, fibrocytes and mesenchymal stem cells (MSC) - thus (as far as I am aware) the "mesenchymal stem cells" are a sub-population of the stromal fraction (if that makes sense)?
MSC also have a defined set of characteristics and cell surface markers to allow them to be identified such as being HLA-DR negative, CD90 positive etc. (Dominici et al 2006).
Most of the cell surface markers (apart from the lack of MHC class II protein HLA-DR) are also shared with the fibroblast fraction (indeed I believe MSC to be a secretory form of fibroblast).
It should be noted that early nomenclature used to term the MSC "mesenchymal Stem Cells" but it has since been recognised that the "MSC" fraction are not truly stem cells as such (they have a limited capacity for division in vitro" so they are now more generally called "mesencymal stomal cells".
I hope this helps!
Gary
I agree with Gary,
For instance, you see different names for Adipose Tissue derived Stem cells" nowdays they also called Stromal cells or fibroblast-like cells. Same for MSC.
Hello
i agree with Gary Morley and Mojtaba Parvizi
Bone marrow stromal stem cells (skeletal stem cells) A multipotent subset of bone marrow stromal cells able to form bone, cartilage, stromal cells that support blood formation, fat, and fibrous tissue. BM-MSC subpopulation of the stromal cell with the character of adherence to plastic surface and fibroblast-like appearance in culture .
in general Mesenchymal stem cells , Cells from the Mesenchyme embryonic connective tissue. A number of cell types come from mesenchymal stem cells, including chondrocytes, which produce cartilage , osteoblasts (bone cells), muscle cells and adipocytes (fat cells). MSCs in culture express on their surface CD73, CD90 and CD105, while lacking the expression of CD11b, CD14, CD19, CD34, CD45, CD79a and HLA-DR surface markers .
Good Luck
From the statement of ISCT in 2006, they mentioned the MSCs are stand for mesenchymal stromal cells (stromal origin) and they set the minimal criteria for MSCs characterization same as the above comments. They cannot assume whether these cells are stem cells due to lack of appropriate characterization steps. However, using mesenchymal stem cells is acceptable.
Hope this can help
- Badges
- Science method