Can anyone recommend a good marker for activated microglia?

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Volodya Hovhannisyan

Hi! CD68 is a marker for activated microglia and widely used in the litterature but it is not specific to microglia given that activated macrophages can also express it

Samir Ranjan Panda

Hi Jacquelyn Salzbank

You can try using CX3CR1as it specifically is expressed in the microglial cells (CX3CR1 regulates microglial recruitment to the sites of inflammation in the brain). Additionally, CD-68 and CD-45 can be used in FACS sorting to identify the activated and ramified microglia.

Hope it helps.

Thanks