Is there a correlation between the number of days premature infant required mechanical ventilation increase chance of requiring or needing bronchodilator therapy?
Lengthening mechanical ventilation duration increases the odds of receiving a bronchodilator. However there is not a lineer correlation. (Inhaled bronchodilator use for infants with bronchopulmonary dysplasia.J Perinatol. 2015 Jan;35(1):61-6. doi: 10.1038/jp.2014.141. Epub 2014 Aug 7.). In addition, It depend also mechanical ventilator mode that is used. (Neonatal ventilation strategies and long-term respiratory outcomes.Early Hum Dev. 2014 Nov;90(11):735-9. doi: 10.1016/j.earlhumdev.2014.08.020. Epub 2014 Sep 16.)
Hello! I don't understand what is the correlation between the ventilatory mode and bronchodilator use in pediatrics... There really any correlation between these two variables? Can the ventilatory mode play a role in this situation?
When on a ventilator the delivered inhaled volume of gas is usually a tidal volume. With this volume of gas the medication deposits more in the upper airways. The inspiratory flow-rate will also be important. If possible use a slower rate during medication administration for better deposition. Medication administration by aerosol is best delivered by a slow inspiratory capacity breath with a 2 to 4 second breath hold for deposition. You don't have that option on a ventilator. Also, use a high quality nebulizer when delivering medication inline with a ventilator. Many times a nebulizer used for spontaneous breathing is used which produces a substandard aerosol for ventilator use.
Thank you for the reply. I am doing a research on number of days neonatal infants received Albuterol treatments while placed on conventional vent versus high frequency oscillator. If the mode of ventilation does play a role on these infants that require bronchodilator therapy.
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