Can anyone provide advice on the study of APOE transgenic cell lines ?

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Tanya Cupino

I'm not aware of any commercially available cell lines that are specifically ApoE characterized. However, the attached paper was published under Dr. David M. Holzman at Washingtion University in St. Louis in 2005. It describes the isolation and characterization of cells like those you describe. They are immortalized astrocyte lines derived from human ApoE knock-in mice. I don't know him personally, but you may be able to contact him for a more information.

http://infoscience.epfl.ch/record/142120/files/Y1235.pdf

Kiran Bhaskar

@Abdelaziz,

Please checkout this website for AD iPSCs. There is one for ApoE4:

http://www.axolbio.com/axol-alzheimers-disease-neural-progenitor-cells-ad-hnpcs.html

Thanks!

Kiran