I am working with mammalian cortical pyramidal neuron model. I have been scanning through literature and have found various firing rates being described between a wide range of 0.2-400 Hz(approximately). I understand that it is because the firing frequency diversely varies itself within the cortex . Also, the rates vary as per the inputs from the surrounding neurons.
But to capture the essence in a computational framework, I need essentially a narrow range within which I can validate my model. Anybody, whose working on in vitro studies of cortical pyramidal neuron(that too at the single cell level), please provide me with a reference for the same.
Alongside, I have another doubt, whenever we talk about fast spiking neurons in the cortex, is it necessary that they should be interneurons? Doesn't the cortex have excitatory neurons that fire at very high frequency like 150 Hz?
Dear Karischma,
if you interested in real firing of cells why do you limit to those who are working in vitro??? If you need personal experience from freely moving rat, tell me. Zsolt
Dear Zsolt,
I asked for in vitro experimental results as I presumed that in vitro experiments are more controlled in the sense that the firing rates of the neuron would be representative of the characteristics of the neurons(like ion channel types, etc) and simply the current applied to the neuron. (which is similar to what we simulate computationally)
In vivo neural recording would be rather different as we dont probably know what all inputs(excitatory or inhibitory) are approaching the particular neuron. But, you being in the mainstream experiments would be able to answer the question aptly. :)
SO I would be definitely interested to know the invivo firing rates of the cortical neuron of rats.
Thanks,
Karishma
I'm recording medial prefrontal area layer 2/3, in freely moving rat, with glass electrode. I search for interneurons but on the way I see many pyramids, even labelled some accidentally. These what I write are not well established results rather assumptions.
-I would set the range to max 200Hz as I haven't seen pyramid firing faster than that (a long trace may few have doublets little faster than that but can not maintain it)
-from tha many cells I have seen in the awake behaving animal I did not see a single bursty (Complex spike pyramid - that would push this limit higher)
-So far the fast spikers I labelled were all proved to be IN (one questionable - deep layer).
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