ZINC, last I checked, cannot do virtual screening: it is simply a database of molecules.  If you want to do screening, you'll need software (docking, QSAR, or some other method).  Then download the molecules from ZINC, and then run them through your software, docking them, comparing them to a QSAR model, etc.

Hi

Please use istar web platform:

By istar, you can perform LBVS and SBVS on ZINC database