Can any one please tell me where the amyloid beta aggregations (plaques) are depositing? I mean which part of the brain we can find more amyloid plaques? Do anyone have papers on that? I couldn't find a proper article to quote.
Dear Dileep Vijayan, the most significant brain amyoid depositions are found in cortex and hippocampus. Have a look at this paper as well:
https://www.karger.com/Article/Pdf/369101
Hope it will be helpfull
Dear Dileep,
The abeta plaques deposition in Alzheimer's disease was nicely described and staged by Thal and coworkers leading to the so called "Thal phases" of Abeta deposition.
Please review the princept paper about it:
Phases of A-deposition in the human brain and its relevance for the development of AD Dietmar R. Thal, MD; Udo Rüb, MD; Mario Orantes, MD; and Heiko Braak, MD
Neurology 2002
Best
Simon
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