I was interested to know, are the PC12 cell lines used for neural differentiation investigation instead of neural progenitor/precursor cell ? how much do they have the same properties as these neural progenitor cell?
PC12 cells stop dividing and terminally differentiate when treated with nerve growth factor or dexamethasone. This makes PC12 cell lines useful as a model system for neuronal differentiation and neurosecretion.
Yes, PC12 is one of the best model to study neuronal differentiation studies. These cells get differentiated with the help of NGF and will work as a perfect model of neuronal development, differentiation and neurosecretion.