I'm working on the protection of the hydroxyl group attached to the fifth carbon. Are there any reagents that you would recommend at this point? What might I need to pay attention to in the process of this synthesis? I ask for your advice. Best Regards
Dear Havva Betül İstanbullu thank you for you very interesting technical question. A generally applicable method to protect hydroxyl groups is the derivatization with a tert-butyldimethylsilyl group. Please have a look at the following relevant references
1. Protection of hydroxyl groups as tert-butyldimethylsilyl derivatives
Article Protection of hydroxyl groups as tert-butyldimethylsilyl derivatives
2. tert-Butyldimethylsilyl ethers
https://www.organic-chemistry.org/protectivegroups/hydroxyl/tbdms-ethers.htm
3. Article Protection of hydroxyl groups as tert-butyldimethylsilyl derivatives
Dear Frank T. Edelmann ,
first of all, thank you very much for your time and attention. During this time, I did my experiments by getting support from the articles you sent. For now, I have achieved 80% efficiency, thank you for your help.
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