Does molecular weight of hyaluronic acid effects size of the nanoparticle synthesized from it ...???

We are preparing hyaluronic acid ( Molecular weight 50 kda) nanoparticles by desolvation process but getting higher size of 800 nm. Can anyone suggest alternative to get lower particle size of...

19 February 2018 3,438 1 View

Can someone advise me How to add Electrothermal body force(ACET) in COMSOL MULTIPHYSICS ?

25 November 2015 4,692 2 View

What do you do to avoid clumping of MSCs which causes immediate death during i.v. injections in mice?

we would like to avoid mice death?

23 September 2014 6,579 1 View

What are some new applications of Isobutanol?

I am aware of the current applications of Isobutanol as a solvent, or transportation fuel etc. I am looking for any novel recent research being conducted for different uses of Isobutanol, say to...

20 June 2014 7,679 9 View

What are the criteria and indicators for measuring the health of bamboo forests and bamboo clump (species - Dendrocalamus strictus)?

How does one measure the health of a bamboo forest? How does one measure the health of bamboo clump? Are there any models available that can help us simulate the future of a bamboo clump, based on...

01 January 1970 2,767 2 View

Protein-aptamer gel electrophoresis help, please??

Hi, I have problems with running gel electrophoresis. I have tried agarose gel electrophoresis and native PAGE. I have two proteins, which have molecular weights of ~30kDa and ~180kDa and two...

03 March 2021 4,275 4 View

What is the ideal efficiency for a qPCR?

hello everyone, I need to do standard curves for my qPCR, what is the ideal efficiency range? I tried a primer (Mglu2 receptor) that gave an efficiency of 90.2%. Is it accepted?

28 February 2021 1,254 3 View

Can Immunogenic BNT162b vaccines protect HUMANS from SARS-CoV-2?

"A safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates,...

11 February 2021 6,628 9 View

How to find a particular aptamer complementary sequence?

I can find several papers that give me a guide for choosing a suitable aptamer sequence 1. But how to find a property aptamer sequence 2(partially complementary to sequence 1)?

09 February 2021 3,511 1 View

How to Remove different version of atom from pdb Crystal Structure for Docking Preparation?

I am new to Docking and MD, and currently try to catch on it. I try one of the webserver for docking, but unfortunately not working. it says " Your PDB contains multiple forms of the same residue...

08 February 2021 7,426 3 View

Where can I find the receptor binding domain (amino acid sequence) of ALL pathogenic viruses?

I want to compare the RBD of all pathogenic viruses? Is there a database or manuscript that anyone knows of where I can access these?

25 January 2021 3,843 4 View

How do I dissociate an antibody used for positive selection of cells in order to re-culture the selected cells?

Hi, I am interested in cells that express a specific receptor. I use a fluorophore-conjugated antibody bound to the receptor followed by MACS positive selection to enrich for this...

21 January 2021 2,245 3 View

Can anyone helps me with Autodock 4.2 scripts error ?

After opening the file, I operate command "Script" --> "Ligand Interactions" --> "Show Ligand Binding Site Atoms" and the warning appears as "This script displays ligands and surrounding...

15 January 2021 5,360 1 View

Is it possible to predict the conformations of the molecule in the solution based on quantum-chemical calculations?

Hello, everyone and thanks for helping me. My question is: I have a metal complex that has several possible conformations. I need to calculate what conformation is the most plausible in different...

08 January 2021 831 3 View

Do drugs that are injected i.t in rats reach the supraspinal system and how long does it take to clear them from spinal cord?

I am injecting intrathecally (between L5-L6) , in rats, cannabinoid analgesics and I was wondering if they can reach the brain and have effects there as well ? Also I need to pretreat with...

07 January 2021 5,397 4 View