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Questions related to Bioinformatics and Computational Biology
Here is an example. Lets say two SNPs are co-inherited 100% of the times, D' prime will always be 1, while r2 incorporates the information about allele frequencies and thus will be lower than 1 if...
12 December 2016 5,020 6 View
I'm try to use Qiime with RTAX assign_taxonomy method to deal with miseq PE data, which is not sequenced_through the V3 region. but the result turn out to nothing assigned! I follow the Qiime...
12 December 2016 5,163 5 View
Hi all, I'm a R user and would like to perform some quantitative genetics tests. The experimental design is full- half-sib design (each male mated with two females). Thanks in advance
12 December 2016 5,014 7 View
Recently I'm working with functional candidate gene study. so I have three SNP and need to calculate allele substitution effect and additive and dominance effect for single SNP marker...
12 December 2016 3,146 9 View
Dear Researchers, Does anyone have any suggestion regarding pig genome database? I am looking forward to clone promoter regions of certain genes like ALDH1L1 and PDGR alpha of pig but unable to...
12 December 2016 2,879 1 View
In a cDNA sample
12 December 2016 2,285 9 View
what are the best available databases for alternatively spliced isoforms in humans? How ESTs are used for identification of alternative spliced forms?
12 December 2016 1,100 4 View
Hi, I wish to apply in silico methods for analysing the activity of a protein. the protein is actually an enzyme that destroys gram positive cell walls. I wish to model the effect of various...
12 December 2016 6,984 1 View
I want to estimate uptake of Allexa Fluor 647 labelled nanoparticles by fungi Aspergillus sp. in later stages (26 h, containing hyphae). After incubation in well plates together with NPs, fungi...
12 December 2016 5,084 3 View
Bioinformatics or Biostatistics
08 December 2016 6,538 4 View
How I can clean & prepare Protein for MD simulations from the ligand-protein complex?
07 December 2016 6,223 3 View
for protiens
05 December 2016 6,145 32 View
Does anybody have any experiences submitting compete plastid genomes to NCBI. Using their tool sequin is really troublesome and requires a lot of time. Is it easier to deposit the sequences in...
28 November 2016 1,707 3 View
i am planning to use Primer v6+PERMANOVA to analyze metagenomic data, any one have this experience? what is the difference between analyzing metagenomic data and morphological data using this...
22 November 2016 835 3 View
I've just got fragment analysis up and running. I'm using the MapMarker 1000-ROX size standard, which doesn't come as a built in standard in GeneMapper. I've tried manually adding it, but...
14 November 2016 8,428 2 View
Currently, I am looking for databases, which associate SNPs and phenotypes (like eye colour or breast cancer risk). These should get updated regularly with regards to recent GWAS etc. Ideally,...
14 November 2016 5,413 8 View
We have an RAPD genetic data with the usage of 8 loci/primer, for each loci there is about 13-18 "allels". My problem is that I am stucked at the beginning. I dont know how shall I need to prepare...
11 November 2016 8,491 2 View
Differentiate bi-allelic and multi-allelic molecular markers?
11 November 2016 4,628 0 View
As we know antibiotiic resistance is a dire clinical problem with important ecological dimensions. It is in human pathogens continues to rise at alarming rates.I am searching for antibiotic...
11 November 2016 2,806 5 View
My background is in computer science, and I have a method which may be able to relate a disease to its expression in DNA. I wish to test this out. Are there any free data sets which contains raw...
11 November 2016 3,046 6 View
11 November 2016 4,215 3 View
11 November 2016 3,990 3 View
11 November 2016 1,827 2 View
I've recently done a ChIP-seq analysis with a protein I'm interested in and found that this protein is highly enriched in intergenic and intron regions. I suppose that most of the genomic...
11 November 2016 5,002 3 View