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Questions related to Bioinformatics and Computational Biology
I am currently trying to find homologues of a protein I am working with, but BLAST has been giving me nothing useable. I have now found a dataset of 1500 protein sequences of potential candidates...
27 June 2019 5,870 2 View
Dear altruist, I am working on Bioinformatics and Computational Biology. I am using Cytoscape tool for network visualization or analysis. Now I am working on lung cancer-related genes. In this...
22 June 2019 8,498 1 View
What are your thoughts on showing that P vs NP is undecidable by proving that solving it is equivalent to solve the halting problem using a form of self-referential argument, like Godel did in his...
09 June 2019 5,787 1 View
06 June 2019 3,656 3 View
06 June 2019 6,620 3 View
I am very new to RDKit and it is extremely confusing. I have a set of ligands. I have taken their SDF files as well. Now I need to find the common core structure among all the ligands. So I am...
31 May 2019 7,685 1 View
I mean what should be the maximum number of control variables in a model. Is there any limit? OR I can take as many as possible. AND How the number of control variables can affect the estimates?
21 May 2019 6,447 6 View
We often perform alpha/beta diversity on OTU that created from subsampled data. Some other analysis, like taxonomy profile(abundance figure of different bacterial communities), PCA, RDA...
16 May 2019 2,246 3 View
While going through various articles, I found the common practice of selecting a particular chain over others if a protein is in multimeric form. In this regard, I have the following questions 1)...
07 May 2019 4,063 5 View
I’ve used the same normalization and chip to search a gene expression in R2 Genomics Analysis and Visualization Plataform, but I have compared very different cells (like lung cancer and melanoma)....
14 April 2019 5,585 1 View
Hi community members ! I would be very happy to recieve advices from you. I have scRNA-Seq data and would like to start with the analysis part. I already went through QC and alignment process but...
11 March 2019 4,644 6 View
03 March 2019 1,146 5 View
For the bioinformatic and the computational biology research what are the best and ideal PC or workstations and what should be the specifications and how much it will cost?
10 February 2019 1,606 5 View
02 February 2019 2,520 5 View
I just want to clear a doubt related to the content included in both the fields... In both fields we study biology /biotechnology with the help of information technology or computers,then what's...
02 February 2019 1,587 1 View
Hi everyone. Let's suppose that we have an index which summarizes an event of a real-life situation. Let's suppose then that we want to compare the same index of two patients and one index is way...
28 January 2019 4,095 4 View
I'm trying to use homology modelling to find the structure of the N-terminus of a protein which is thought to contribute to its hetero-oligomeric structure. However, I can't find an x-ray...
25 December 2018 6,963 3 View
I want to know if there is an online server for ligand-protein complex docking with another protein. The available renowned protein-protein docking servers like ClusPro, HADDOCK, PyDock etc....
20 December 2018 4,825 12 View
Hi, I have modeled two protein structure, which has antigenic sites. I am planning to study the interaction of those protein with Ig G. What's the best strategy for protein-immunoglobulin...
12 December 2018 2,192 1 View
where can i find good molecular dynamics simulations papers without experimental (wet lab) counterparts. This is for computational biologist without a wet lab set up. Given that most journals...
12 December 2018 8,495 10 View
12 December 2018 5,016 13 View
I have tried to predicted the 3D structure by using multiple online softwares like I-TASSAR, MUSTER, Swiss-Model and (PS)2 but predicted 3D structure from each software has bad quality and can not...
28 November 2018 9,206 3 View
11 November 2018 5,681 6 View
I am interested in performing MD simulation for one of the DNA demethylase enzymes using Amber. I have been able to generate both the "mol2" and "frcmod" files for the non-standard residues using...
15 September 2018 3,301 2 View