Dear Researchers,
There will be an impact in the binding of G-quadruplex DNA with the anticancer drugs due to different PH and temperature environment in our body. During the simulation how these PH and temperature should be treated with. (how to choose the proper environment). I have done a simulation under the neutral PH (7.4) and acidic (5.5) environment, since in most of the literature these level have been used towards the cancer therapy. But I am so confused about choosing the temperature environments. In addition to the neutral temperature (300 K), what will be the most effective temperature environment should be considered towards the cancer therapy? Suggestions will be highly appreciated.
With regards,
R. Radhika
PH is the power of hydrogen, in other words concentration of hydrogen i.e in the normal temperature 300k when PH value around 7, which mean that neutral. Mostly you proceed simulation neutral ph is good, some time temperature will go high, Ph goes to low, the hydrogen bond has not been formed, that situation may comes. My point of view, u perform the system at both low and high ph, and than compare them. Bio physical technique poin of you, i have less idea. go ahead.
Dear Dr. Boopathi & Dr. Martin Klvana,
Thanks for the response. I will go through that.
Sincerely,
R. Radhika
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