Paulo Magno Martins Dourado

21 Questions 39 Answers 0 Followers

Questions related from Paulo Magno Martins Dourado

It is worth using statins as myocardial protection strategy on the set of acute myocardial infarction?

I will start an experimental study in infarcted rats to evaluate the additional role of statins in myocardial protection. I think of studying two drugs: pitavastatin and rosuvastatin in various...

23 May 2016 124 5 View

Is the use of statins an effective strategy to reduce inflammatory response during ST elevation myocardial infarction?

Following ST Elevation Myocardial Infarction (STEMI) the myocardial ischemia causes an inflammatory response, which is a predictor of mortality and myocardial remodeling. Treatment with statins...

03 September 2015 1,177 9 View

Are the compounds that enhance GCH1 expression a new target in the treatment of atherosclerosis?

Some studies showed that eNOS-derived reactive oxygen species play an important role in atherosclerosis progression and restoration of eNOS functionality by upregulation of GCH1 is a rational...

19 April 2015 9,067 4 View

Beyond statins, what are the best strategies to fight against LDL cholesterol and development of atherosclerosis?

LDL cholesterol remains the proven target. Many alternatives have been presented. The possibilities debated involved cholesteryl ester transfer (CETP) protein inhibitors, apolipoprotein B (apoB)...

08 April 2015 6,506 11 View

Are statins able to reduce myocardial infarct size and improve myocardial remodeling?

Dyslipidemia is related to the progression of atherosclerosis. Although treatment of dyslipidemia is beneficial in decreasing the number of coronary events its effect on infarct size and...

08 April 2015 1,379 15 View

What is the next in coronary artery disease prevention?

The essential logic is to decrease the time of exposure to cardiovascular risk factors with genetic insights providing strong justification for this approach. Lifetime exposure to lower...

28 March 2015 8,642 26 View

Are PCSK9 Inhibitors really ready to be used?

A new class of cholesterol drugs - the PCSK9 inhibitors - might reduce the risk of heart attacks and strokes, and some trials were recently presented demonstrating these evidences, but we do not...

17 March 2015 3,390 5 View

Does anyone have experience with the use of echocardiographic contrast in pregnant women ?

With the increasing use of echocardiographic contrast for both endocardial border delineation , and in the evaluation of myocardial perfusion , we are faced with the indication for the procedure...

14 March 2015 9,059 5 View

What are the newest perspectives in Cholesterol reduction?

Statins are the main weapon in the fight against cholesterol, which enabled reduction of morbidity and mortality, however many patients do not tolerate it and others do not reach the recommended...

08 October 2014 7,126 11 View

Where are we with therapeutic use of ultrasound in acute and chronic arterial disease?

Recent studies have shown to be feasible the use of thrombolysis by ultrasound. This is really a new therapeutic window? What we need to move forward to achieve this purpose?

14 September 2014 6,187 3 View

Does the 3D stress echocardiography (RT-3D) really bring an additional gain in the diagnosis of coronary artery disease?

Recent studies have reported an increased use of 3D stress echo in the diagnosis of coronary artery disease. This method really is ready for use in clinical practice?

01 September 2014 315 4 View

Where are we with assessment of systolic function by echo?

The indication for echocardiography to evaluate systolic function of the left ventricle represents a major clinical applications of this method and new diagnostic techniques have been proposed....

19 August 2014 7,166 9 View

What is the best technique to assess blood flow in mice?

I'm developing a new survey that measured blood flow by Doppler echocardiography in mice will be necessary to determine the degree of residual flow after femoral artery stenosis and I would like...

18 August 2014 2,817 4 View

What is the most likely mechanistic link between NADPH oxidase activity and muscle atrophy in infarcted rats?

NADPH oxidase hyperactivation is an important source of ROS production and consequently leads to myocardial infarction induced atrophy and some studies have shown that cardiac dysfunction after MI...

24 May 2014 441 0 View

What is the best strategy to evaluate the role of inflammatory cytokines in acute myocardial infraction?

I wonder what would be best way to evaluate the role of inflammatory cytokines in outpatient clinical trials in acute myocardial infraction?

27 April 2014 2,022 10 View

Does contrast echocardiography predict the site of future myocardial infarction?

I would like to know if the area with a perfusional defect on a contrast echocardiography corresponds to the site of future myocardial infarction.

05 April 2014 2,855 4 View

What are ways for high levels of dysfunctional HDL to induce minor flow-mediated dilation and nitric oxide production in myocardial infarction?

I am interested in knowing the ways of high levels of dysfunctional HDL in the acute phase of myocardial infarction induce minor flow-mediated dilation and nitric oxide production and the...

29 March 2014 5,032 1 View

What's new on the peri-coronary fat as a new target of research in the development of atherosclerosis?

I would like to know about the strategies that are being developed to evaluate the role of peri-coronary fat in the development of coronary artery disease, mainly on the use of cardiac imaging and...

05 March 2014 8,348 3 View

What is the best strategy for using ultrasound therapy in acute arterial disease?

What intensity of ultrasound energy is used to dissolve thrombi and is there a standard protocol available?

26 February 2014 1,997 8 View

Is contrast echo ready to be used for the diagnosis of coronary artery disease?

What is the best strategy - tredamill stress test or chemical stress with dipyridamole or dobutamine?

24 February 2014 2,014 7 View

What is the best strategy to evaluate paradoxical low flow low gradient aortic stenosis?

I would like what is the methods you are using to evaluate paradoxical low flow low gradient aortic stenosis

17 February 2014 2,172 18 View