Paulo Magno Martins Dourado

14 Questions 30 Answers 0 Followers

Questions related from Paulo Magno Martins Dourado

Is the use of statins an effective strategy to reduce inflammatory response during ST elevation myocardial infarction?

Following ST Elevation Myocardial Infarction (STEMI) the myocardial ischemia causes an inflammatory response, which is a predictor of mortality and myocardial remodeling. Treatment with statins...

03 September 2015 1,142 9 View

Are the compounds that enhance GCH1 expression a new target in the treatment of atherosclerosis?

Some studies showed that eNOS-derived reactive oxygen species play an important role in atherosclerosis progression and restoration of eNOS functionality by upregulation of GCH1 is a rational...

19 April 2015 9,037 4 View

Beyond statins, what are the best strategies to fight against LDL cholesterol and development of atherosclerosis?

LDL cholesterol remains the proven target. Many alternatives have been presented. The possibilities debated involved cholesteryl ester transfer (CETP) protein inhibitors, apolipoprotein B (apoB)...

08 April 2015 6,478 11 View

Are statins able to reduce myocardial infarct size and improve myocardial remodeling?

Dyslipidemia is related to the progression of atherosclerosis. Although treatment of dyslipidemia is beneficial in decreasing the number of coronary events its effect on infarct size and...

08 April 2015 1,346 15 View

What is the next in coronary artery disease prevention?

The essential logic is to decrease the time of exposure to cardiovascular risk factors with genetic insights providing strong justification for this approach. Lifetime exposure to lower...

28 March 2015 8,611 26 View

Are PCSK9 Inhibitors really ready to be used?

A new class of cholesterol drugs - the PCSK9 inhibitors - might reduce the risk of heart attacks and strokes, and some trials were recently presented demonstrating these evidences, but we do not...

17 March 2015 3,352 5 View

Does anyone have experience with the use of echocardiographic contrast in pregnant women ?

With the increasing use of echocardiographic contrast for both endocardial border delineation , and in the evaluation of myocardial perfusion , we are faced with the indication for the procedure...

14 March 2015 9,033 5 View

What are the newest perspectives in Cholesterol reduction?

Statins are the main weapon in the fight against cholesterol, which enabled reduction of morbidity and mortality, however many patients do not tolerate it and others do not reach the recommended...

08 October 2014 7,103 11 View

Does the 3D stress echocardiography (RT-3D) really bring an additional gain in the diagnosis of coronary artery disease?

Recent studies have reported an increased use of 3D stress echo in the diagnosis of coronary artery disease. This method really is ready for use in clinical practice?

01 September 2014 268 4 View

What is the best technique to assess blood flow in mice?

I'm developing a new survey that measured blood flow by Doppler echocardiography in mice will be necessary to determine the degree of residual flow after femoral artery stenosis and I would like...

18 August 2014 2,782 4 View

What is the most likely mechanistic link between NADPH oxidase activity and muscle atrophy in infarcted rats?

NADPH oxidase hyperactivation is an important source of ROS production and consequently leads to myocardial infarction induced atrophy and some studies have shown that cardiac dysfunction after MI...

24 May 2014 408 0 View

What is the best strategy to evaluate the role of inflammatory cytokines in acute myocardial infraction?

I wonder what would be best way to evaluate the role of inflammatory cytokines in outpatient clinical trials in acute myocardial infraction?

27 April 2014 1,982 10 View

Does contrast echocardiography predict the site of future myocardial infarction?

I would like to know if the area with a perfusional defect on a contrast echocardiography corresponds to the site of future myocardial infarction.

05 April 2014 2,816 4 View

What's new on the peri-coronary fat as a new target of research in the development of atherosclerosis?

I would like to know about the strategies that are being developed to evaluate the role of peri-coronary fat in the development of coronary artery disease, mainly on the use of cardiac imaging and...

05 March 2014 8,316 3 View