I'm developing an experimental study in mice in which need to determine the presence of peripheral arterial disease and I would like to establish the best strategy to define this clinical situation.
Since the patient affected by claudicatio intermittens cannot walk too much, the best strategy I guessc ould be to set a distance that claudicants mice cannot walk, and normal mice can. For example, a "rolling wheel " test, measuring the total walking time, or something like that.
Dear Paulo Magno Martins Dourado ,
We did an experimental study in mice based in a Critical Lower Limb Ischemia in an Animal Model.
After they were anesthetized and their femoral arteries were ligated the degree of ischemia was monitored for 4 weeks using a visual scale. Muscle atrophy and strength were assessed at 4 weeks postoperatively; the mice were then killed.
Article Impact of Angiogenic Therapy in the Treatment of Critical Lo...
if you mean peripheral artery occlusive disease in patients the most accepted criteria is an ankle brachial pressure index less than 0.9. If you are not clear what ABPI is please let me known and I'll explain. In mice often laser Doppler is used to assess peripheral perfusion in comparison to a control leg.
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