Dear Colleague,

For Cerebrovascular disease and stroke . Sonothrombolysis is a good tool , you will find a lot of publications about Sonothrombolysis in acute Stroke .

And for peripheral arterial disease someone has a great experience?

Hi Paulo,

I`ve no idea about ultrasound therapy in acute arterial disease. That`s a good question!

I think it is a good alternative in a near future, mainly its use in peripheral thrombolysis, but certainly in the future it will be used to coronary artery disease. I think the best strategy is use microbbubles with high ultrassound energy to reperfund the vessel. How to do it? I have some ideas, but first is necessary to develop it in animals models.

You think about which animal ?

I think it is possible to do these experiments in any animals, and in our labs of research is possible to do it in rabbits or wistar rats.

We worked with BALB/c mice in a ischemic of lower limbs animal models. They were anesthetized and the femoral, deep femoral and popliteal arteries were ligated and severed. You think it is possible ultrasound therapy in mice? It would be easier and cheaper...

I think it is possible to perform these studies in mice. What is the ultrasound machine that you use? It allows assessment of perfusion in real time and contrast enhancement? You will need to apply high energy pulses for the dissolution of thrombi. How has the mHz probe you use? A probe from 20 to 25 MHz is required. The machine that I know that has these transducers is the Visual Sonic.