This project is in a rare type of lymphoid cancer. Due to this rarity, there are only 3 cell lines available for the disease, which I have in the lab. They are drug-sensitive cell lines (drug disclosed only if you are interested in collaboration) and I also have their 3 drug-resistant clones, which were developed in the lab (so total sample n=6). Unfortunately, I do not have any patient samples. I wish to conduct RNA-seq to examine changes at the mRNA level as well as SNV's in these cells. The goal is to identify changes that characterize drug-resistant cells vs. their drug-sensitive WT counterparts. Please tell me if this type of an analysis is possible with such low sample numbers? If so, please let me know if you are interested in collaborating to analyze the resultant RNA-Seq data?