Many papers report no effect of polyphenol supplementation in healthy people, but a positive effect in those with abnormal baseline values.
Mechanistically speaking what could be the reasons for this?
Presumably, in healthy subjects the mechanisms (or mechanistic pathways) that a given polyphenol may operate by is not being activated.
you should use appropriate biomarkers who can judges absorb or not, and second things therapeutic results can see easily in patients but already health person how can sèe effects?.
select appropriate experimental and control samples
What improvement do you anticipate to observe in healthy people or animals????
I was looking to see if cherry anthocyanins could improve lipid and glucose markers in blood.
It could be that healthy people have sufficient (which is one reason they are healthy) and more is not going to accomplish more for them. Unhealthy people may be low in polyphenols possibly due to poor diet or possibly due to disease process that is using up what they have faster.
Yes,
I was thinking there may be a defensive mechanism activated by the body in response to excessive consumption of antioxidants, suggesting a hormetic effect?
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