Why we select 90 days for glaucoma study to evaluate any new drug efficacy in clinical trials?

03 April 2020 0 3K Report

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Can anybody guide me for How to solve polynomial equation for checkpoint analysis in formulation development"?

I have done formulation development of tablet for which i have considered two independent variable. Results are plotted in a statistical analysis software and polynomial equations are generated....

24 April 2024 3,951 1 View

How we can increase the strain harednability of C250 maraging steel to improve its high strain rate properties?

Experiment is about tuning of microstructure of low carbon/carbon less martensite with various amounts of reverted austenite by controlling aging temperature and times.

10 April 2022 362 0 View

How much strain rate of deformation is necessary in hot forging of Austenitic stainless steel to achieve complete recrystallization and fine grain?

Austenitic stainless steels are prone to coarse and mixed grain size after hot working by forging or rolling untill forging start and finish temperature and final pass strain rate are...

06 December 2021 6,356 2 View

How much change in hot and cold formability will be there if alloys with poor fomabilty is forged or rolled under vacuum?

Some of alloy steels and superalloys have very small forging window and one faces problem of cracking during hot forging and rolling and are preferentially isothermally forged.It could be...

27 January 2020 2,724 2 View

What shall be effect of strand EMS on SDAS and denderites cell size in high speed steel M2 continuous casting?

In high speed steel M2 grade used for making tools like drills, rimmers and threading taps, two things are of paramount importance; 1. Primary carbides 2. Cell size both of these are resulting...

04 August 2019 3,079 0 View

How to avoid under riser cracks in 40 ton P92 casting?

Even after following specified heat treatment from knock out to final HT ,delayed intergranular cracks observed under all riser cutting locations and near chills in 40 ton P92 castings.What are...

03 August 2019 5,735 9 View

15-5Ph, steel shafts get longitunally cracked in processing , can some one suggest remedy?

Cracking in 15-5Ph precipitation hardening stainless steel in cast electrode,, ESR/VAR ingot , post forging cooling and heat treatments in industrial manufacturing of forged semis .Precautions...

30 July 2019 364 1 View

What microstructural and physical changes will happen if high hardenability steel sample after quenching is kept for self aging for six months?

To study the effect of self aging in low alloy medium carbon steels and high chromium air hardening martensitic stainless steels, various steel grade samples are under study in my research...

30 July 2019 3,095 6 View

Liquidus temperature of 21-4N austenitic exhaust valve steel?

This grade of steel has following composition; carbon 0.48-0.58% Mn 8.00-10.00% Si 0.25 max Cr 20.00-22.00% Ni 3.50-4.50% N...

31 March 2019 6,594 0 View

What is state of art in titanium stablized heat resistant austenitic stainless steel?

Greetings of the day to all fellow researchers; I am trying to design and develop titanium stablized AISI 321H for nuclear application with good high temperature yield strength and creep strength

01 July 2018 5,130 3 View

Is changing the medium during the experiment overestimate the results?

I am experimenting with cancer and non-cancer cells in a 12-well plate for 4 days with a seeding density 1*10^4/well, however, I noticed that the control group growth rate slows down on D3. Should...

07 August 2024 2,283 2 View

Which solvent is better to dissolve with secondary metabolites extracted from fungi?

I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...

03 August 2024 4,725 2 View

Can i quantify a nanoparticle encapsulated in cell culture medium by hplc?

Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...

03 August 2024 2,730 1 View

How to maintain the drug concentration in cell culture study for long term?

I am working in the filed of long acting drugs with Nano formulation. I want to study the efficacy of my formulation in 2D cell cultures while this required media change on every two days. In such...

24 July 2024 8,696 0 View

How can I determine if a drug binds to a ribosome using a Cryo-EM map?

Hello, I am searching for the binding position of a drug in a ribosome, based on previous work indicating it binds there. The resolution of the ribosome-drug Cryo-EM map is around 2.5 Å. I've been...

19 July 2024 2,155 0 View

How to calculate percentage cumulative drug release?

How to calculate percentage cumulative drug release when, Total volume of dissolution media = 250ml Added formulation was equivalent to 10mg of drug Sample withdrawn = 1ml each time Sink condition...

15 July 2024 4,192 1 View

MTT assay - 6 well plate?

Hi, In the 6 well plate, when I am seeding the cells. Do I add 1ml of complete media to one of the wells for the control at this stage or do I wait unit I am treating the plates to do that? Also...

13 July 2024 9,783 1 View

How to convince decision makers to adjust the legislation to allow opening of drug consumption rooms?

In my country, there is a lot of public outcry in relation to the presence of drug injection and related behaviors in public. Hence at least the bigger cities would probably benefit from the...

08 July 2024 8,903 1 View

Is the use of microcrystalline cellulose MCC 102 in direct compression technology justified, given the low flowability of this excipient?

Hello everyone reading this topic! It is well known that microcrystalline cellulose 102 is recommended for use in direct compression technology, however, like other grades, it has poor flowability...

08 July 2024 2,807 0 View

What are the trending topic to writ e a review article on it?

The topic should relate to pharmacy ,drug, methos of drug discovery, or any other topic but related to dug or pharmaceutical field

02 July 2024 4,031 3 View