Hello everyone reading this topic!
It is well known that microcrystalline cellulose 102 is recommended for use in direct compression technology, however, like other grades, it has poor flowability (does not flow through a funnel with a hole diameter of 10 mm). We developed the composition of the prototype as the reference drug using microcrystalline cellulose 102 and lactose 80 mesh as fillers in a 2 to 1 ratio, respectively. The composition contained aerosil at a concentration of 0.5%. The resulting tablet mass had a flowability of 3 g/sec with pulsations and a Hausner criterion of 1.25 (Fair/Passable). In a research laboratory, we do not have the opportunity to simulate high-speed tableting as on an industrial tablet press in order to assess the tendency of the tablet mass to hang in the hopper in order to assess this risk in future technology transfer. To what extent can the obtained tablet weight indicators be considered acceptable?
- Badges
- Science topic
- Similar topics
- Biological Science
- Biochemistry
- Biochemical Techniques
- Analytical Chemistry
- pH