I have fabricated PCL scaffolds with incorporated paracetamol using single-nozzle electrospinning. I assume that during the solvent (HFIP) it was partitioned towards the surface, since a burst release was observed during the dissolution study. Is such result somehow connected to the polarity of the solvent or is it simply based on polymer-drug interaction?
Dear Danila
In addition to polymer drug interaction polarity of spinning voltage has an effect on drug realease
http://electrospintech.com/chargemolecule.html#.WJGgK_JlG80
Regards
Marc
your drug not only resides on surface it will be inside the fibers too. if you can bind the drug with specific fluoresent dye and then analyse the fibres with fluoresent microscopy you can get the exact distribution.
Dear Arun
I have calculated the amount of the incorporated drug, and according to that, most of the drug was almost instantly released. For sure, some amount stayed inside the fibers and would not release till the fibers start to degrade. Thank you for the advice regarding using fluorescent dye to map the drug.
Cheers
Dan
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