15 January 2021 5 6K Report

I purified my Boc-protected molecule using HPLC. The eluent is ACN/H2O/(0.05% TFA) . After I evaporated the solvent (65 oC), the product was collect as the MS result showed ~20% of the product was boc-deprotected. Why could this happen? And how to avoid this? I need your help!

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