I saw there're many articles depicting the methylation landscape of cancerous and adjacent normal tissues. But there're few articles giving a whole-genome landscape of multiple histone modifications. For example, like liver cancer, many reports are about the methyome, only some articles focused on histone modification on a few important genes. I wonder why there's no data.Is it already a common sense of the histone modification changes during tumorigenesis? Or maybe I missed some important reports that people have done this work very early? Do you think it make sense to compare the histone modification between cancer and normal tissues?
Thank everyone!