Dear Cemre Didem Eyipınar,

Detection kits that are designed with a lower detection limit than the physiological concentration range ensures accurate and reliable measurements, especially when dealing with trace amounts of analytes. This approach helps to avoid issues like background noise and ensures that even very small amounts of a substance can be reliably detected.

Biological processes involving very low concentrations of substances, the detection kits with lower detection limits can essentially be used for studying these trace amounts. In medical diagnostics, a lower detection limit allows for the detection of analytes at earlier stages of a disease, potentially leading to a more effective treatment. 

To accurately detect trace substances in biological samples, it is crucial to use detection kits with a range lower than the physiological concentration range of those substances. The kits are designed with a detection range below physiological levels to be more sensitive, meaning they can detect smaller quantities of the target analyte.

Yes, it is crucial to disclose in published studies when a kit with a lower detection range than the normal physiological range is used. This is important for transparency and to ensure readers can properly interpret the study results. Mentioning the specific detection range of the kit used, along with the normal physiological range, allows for a clear understanding of whether the kit is appropriate for the intended purpose and whether the results are meaningful within the context of the study. 

Regards,

Malcolm Nobre

Malcolm Nobre “In other words, isn't it possible to publish an article produced with data obtained from a population with a detection range lower than the normal physiological range? Can journals reject it directly for this reason?”

Yes, it is possible to publish. But it could face rejection if the findings did not contribute new knowledge or insights, or if the results were not significant.