Hello,
SV40 is not considered an oncogenic virus in this review:Article Oncogenic viruses and cancer
Why is SV40 not considered an oncogenic virus when it produces the large T antigen, which is used to immortalize mammalian cell lines?
Additionally, SV40 proteins have been found in human tumors.
Could this lack of coverage possibly have something to do with the fact that the polio vaccine introduced SV40 into the human population in the late 1950’s? How many people are actually positive for SV40 proteins? How many of these people develop cancer? Why are SV40 proteins not tested for regularly, given that they are an indicator of cancer?
Thanks!
Please have a look at the following RG link.
Article Association Between Simian Virus 40 and Human Tumors
SV 40 is an oncogenic virus.
Read
Carbone, M., Pass, H. I., Miele, L., & Bocchetta, M. (2003). New developments about the association of SV40 with human mesothelioma. Oncogene, 22(33), 5173-5180.
Cicala, C., Pompetti, F., & Carbone, M. (1993). SV40 induces mesotheliomas in hamsters. The American journal of pathology, 142(5), 1524.
McNees, A. L., Vilchez, R. A., Heard, T. C., Sroller, V., Wong, C., Herron, A. J., ... & Butel, J. S. (2009). SV40 lymphomagenesis in Syrian golden hamsters. Virology, 384(1), 114-124.
May be the reason for not considering papovavirus SV 40 as oncogenic is this paper
Mortimer Jr, E. A., Lepow, M. L., Gold, E., Robbins, F. C., Burton, G. J., & Fraumeni Jr, J. F. (1981). Long-term follow-up of persons inadvertently inoculated with SV40 as neonates. New England Journal of Medicine, 305(25), 1517-1518.
Hello David
SV40 can cause human tumors is still controversial in cancer research. Human cells of different tissues have undergone transformation when subjected to SV40 oncoproteins. As per the ‘hit-and-run’ mechanism SV40 could be playing an important role in the initial stages of cancer. Studies have shown that SV40 protein interacts with p53 and pRB proteins. There are many aspects related to SV40 which still need to be looked into for its involvement in carcinogenesis. It is too early to say that SV40 is not an oncogenic virus.
Thank you.
Please have a look at the following RG link.
Article Association Between Simian Virus 40 and Human Tumors
SV40 is a pathogen that has a possible etiologic role in human malignancies.
Article Emergent Human Pathogen Simian Virus 40 and Its Role in Cancer
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