Why does some miRNA sequences of miRbase seem to be protein coding RNAs?

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Prabodh Trivedi Popular answer

I do not know whether you are mentioning mature miRNA or pri-miRNA. Recent paper in Nature has shown that pri-miR transcript codes for peptides known as miPEP. These regulates expression of miRNA genes.

Ajay Saini

Dear Ali,

The results observed by you in Blast Output are not surprising. The miRNAs ar eindeed non-coding RNAs but many of them target coding sequences. So they are complementary to the target sequences. In the Blast output the default setting is see both + and - strand results...see them carefully...

bye

Prabodh Trivedi