How polymerase reads ori site where it is already methylated in GATC sequence ?
According to my knowledge, methylation of DNA is associated with a compact chromatin conformation. This makes DNA inaccessible to DNA polymerases. On the other hand, DNA demethylases remove methyl groups from histones which loosens DNA structure and makes it more accessible to DNA polymerases. Thus, it facilitates DNA replication.
DNA methylation is manly for silencing the gene. During replication or any activity of cell, some genes are turned off and other genes are turned on
@Matthias R. Schaefer, yes sir, and still it remains as a question that how its possible when methylation already took place on Adenine in GATC sequence and replication occurs.
@_Subhash C. Juneja, as per our knowledge methylation leads to silencing , and in case of replication it contrasts , as it is needed for polymerization to get start
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