some drugs are found in combination with caffeine such as:
Cafergot (Dihydroergotamine+Caffeine),
Saridon (Propyphenazone+paracetamol+caffeine),
Excedrin (Aspirin+paracetamol+caffeine)
Phrenilin (acetaminophen+ butalbital+caffeine+codeine)
what is the exact role of caffeine in these combinations? is it to increase the absorption? or to contrast the side effects of these drugs such as respiratory depression?
Caffeine might be work as an analgesic adjuvant.
http://pharmrev.aspetjournals.org/content/45/1/43.short
https://www.vista-biopharmaceutics.com/about1-c1ym
This site basically conveys the interactions of caffeine with other molecules that one must know i . basic physical chemistry and nature of interactions and their strength is most appropriate. at the same time the amount of caffeine in any tablet has to be less than the mental alertness dose.
Article The analgesic effects of caffeine in headache
http://bonhamchemistry.com/wp-content/uploads/2012/01/Caffeine_and_Adenosine.pdf
http://www.bumc.bu.edu/neurology/files/Files/ref3.pdf
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