If silver nanoparticles show excellent antimicrobial activity then at the same time does this imply that their cytotoxic impact on mammalian cells will be more than other metallic nanoparticles? If that is so then for nano-enabled antimicrobial products, can silver be replaced by other metallic nanoparticles (in higher concentrations to compete with silver)?
Parna Ganguli
According to the latest research data, the mechanism of action of silver on microorganism cells is as follows. The cell membrane, which performs protective functions, absorbs silver ions. As a result, cell viability is preserved, but due to the bacteriostatic effect, its division is disturbed. In addition, immediately after the penetration of silver ions into the cell, its enzymes are inhibited, the processes of oxidative phosphorylation and oxidation are uncoupled, which leads to the death of the microbial cell.
Silver nanoparticles have a large specific surface like other nanoparticles, but their ions do not have the properties of silver ions.
There are cells that show cytotoxicity from Silver [sperm cells for example] However, Ag is a broad-spectrum antimicrobial while other metal particles, Zn ,Cu have limited targeted appeal, I am attaching a publication on our Ag particles and the mode of action. I have not investigated cytotoxicity effects with other metal particles .I woudl be interested in doing that
Henry Clemente Sir, thanks a lot for your answer and the attached article, thank you so much!
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