I have read a review paper about stem cells and its relation to good manufacturing grade. It stated that most clinical trials uses porcine-derived trypsin rather than human-derived trypsin to reduce safety issues.
What the safety issues using human-derived trypsin? I have looked into it and found that most vaccines (especially for viruses) uses porcine-dervied trypsin rather the human-derived trypsin
Hello Saif! Usually the use of human-derived reagents is avoided whenever possible due to the potential carryover of hazardous contaminants (eg. viruses, prions, etc.), mind that if a porcine sample is contaminated, its contaminants are likely to infect pigs, not humans, whereas if a human derived sample is contaminated it's a health hazard to you and others around you, and it can seriously compromise the trial.
With this in mind, pig reagents are usually compatible with human samples in biochemical terms.
Cheers!
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