Hello everybody,
CHEK2-related breast cancers are very chemoresistant. Can somebody explain me, why they are so chemoresistant? Anthracyclines are not working here compared to BRCA1-carriers.
best wishes,
Werner
Go J Yoshida
CHEk2-mutated breast tumors tend to be resistant to cell cycle arrest with DNA damage mediated by ATM. Therefore, ATR-CHK1 mutated or ATM-CHK2 mutated tumors can continue to proliferate regardless of the genetic damage due to the chemotherapy.
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Werner Pfeifer
thank you very much for your help.
My question is, is there a connection, for example, to the decreased kinase activity of CHEK2? What is happening on the cellular level?
What would be your answer, if somebody would ask you, why CHEK2-associated tumors are so resistant to chemotherapy?
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