Acute alcohol poisoning, would be my diagnosis....Yellowish fluid in the stomach would be indicative of bile reflux from the duodenum... White fluid would be chyme that got obstructed.. much like a human who is too drunk, bile may build up in the stomach as a acute toxicity response and an anti-peristaltic response of the duodenum in attempt to rid the body of the toxin (i.e. alcohol); but, rats cannot vomit, so the the fluid builds up and the rat will suffer a toxic acute response, based on too much alcohol and stomach contents.. As the duodenum was in reflux mode, it was effectively obstructed so the stomach contents stayed there, not being able to be expelled though vomiting. Alcohol is also well absorbed through the stomach mucosa, so it may be the case your rat died simply of an alcohol overdose associated with acute toxicity from bile and ingested food toxins. As it happened only in one rat may not be surprising; Each individual animal is different, and it is difficult to either monitor exactly the alcohol intake, the food/other intake, the background health status or the susceptibility to alcohol poisoning in each individual.
Hi,
Bloating and abdominal discomfort is characteristics of heaptotoxicity. The stomach was bloated and also filled with semi white liquid. We observed chronic leakage of pigments into the stomach and intestine in rats. Mainly , we noticed yellow fluids in the intestine.
Acute alcohol poisoning, would be my diagnosis....Yellowish fluid in the stomach would be indicative of bile reflux from the duodenum... White fluid would be chyme that got obstructed.. much like a human who is too drunk, bile may build up in the stomach as a acute toxicity response and an anti-peristaltic response of the duodenum in attempt to rid the body of the toxin (i.e. alcohol); but, rats cannot vomit, so the the fluid builds up and the rat will suffer a toxic acute response, based on too much alcohol and stomach contents.. As the duodenum was in reflux mode, it was effectively obstructed so the stomach contents stayed there, not being able to be expelled though vomiting. Alcohol is also well absorbed through the stomach mucosa, so it may be the case your rat died simply of an alcohol overdose associated with acute toxicity from bile and ingested food toxins. As it happened only in one rat may not be surprising; Each individual animal is different, and it is difficult to either monitor exactly the alcohol intake, the food/other intake, the background health status or the susceptibility to alcohol poisoning in each individual.
one rat also died in same condition under 5 fu administration after 3 weeks,but that was not alcohol induced hepatotoxic
Alcohol overdose associated with acute hepatic toxicity. You may reduce dose of alcohol to increase survival rate in your experiment.
It can be as a result of drug toxicity to brain. Adjusting dose is helpful.
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