Which is best statistical model for randomization in respect to animal studies?

07 August 2016 7,609 5 View

Toxicology of Herbal extracts, which will be an ideal guideline and why?

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02 March 2016 5,030 3 View

How can I calculate Cmax, Tmax, AUC, T1/2 in PK/PD studies?

31 December 2015 7,174 6 View

Which type of statistcal analysis can be done for FOB (functional observational battery) data for sube acute toxicity study in Wistar rats?

Study Name : Sub acute toxicity Groups: 6 groups G1 control G2 low dose G3 mid dose G4 high dose G 1R control recovery (satellite group) G 4R high dose recovery (satellite group) observations...

31 December 2015 3,445 3 View

While we performed an ethanol induced hepatotoxicity study we found a balloon like stomach and intestine in a rat and it died. Any explanation?

It happened after week of induction

10 November 2015 830 7 View

What are the hall marks of Ethanol induced hepatotoxicity?

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09 October 2015 983 0 View

1,2,6 Hexanetriol is consumable?

please refer the link

09 October 2015 9,229 0 View

Can anyone advise me on food grade glue?

we are developing a kitchen utensil, which is made by wood please tell about a glue to stick the same with out any toxicity when ingested.

07 August 2015 8,069 4 View

How can I reduce mortality in STZ induced type II diabetes in wistar rats?

03 April 2015 2,789 15 View

Will a 20% glucose feeding reverse the STZ (65mg/kg) action in rats?

03 April 2015 2,074 20 View

How can I measure MMP-1 protein activity or protein level from liver tissue?

Instead of checking only the mRNA level, I want to check the active protein level of MMP-1 in Liver tissue from mice. How can I do that?

03 March 2021 1,763 2 View

Does any one know how i can prepare liver tissue with transmission electron microscope with good fixation?

i have problem in preparation of liver tissue with bad cell organelles and how i can adjust osmolarity

03 March 2021 8,890 1 View

Chlorinated organic formation in odor control scrubbers using hypochlorite?

I'm involved in a study of odor control technologies for municipal wastewater treatment plant. One of the control options involves a chemical 2-stage (acid/alkaline) packed bed scrubber. The...

03 March 2021 3,661 2 View

Ester cleavage conditions?

Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...

01 March 2021 8,766 3 View

Can we distinguish the type of free fluid inside the pelvic and abdominal cavities whether blood or serous fluid using the ultrasound?

during ultrasound examination of acute abdomen, sometimes we see free fluid , can we know the type of fluid ,whether blood or not , using ultrasound only? if yes , what are the sonographic...

01 March 2021 7,476 4 View

Is there any expert in Smart PLS who can help me?

Dear colleagues, I have a manuscript that needs an expert in smart PLS to run the analysis, Is there anyone expert and ready to help me, please?

01 March 2021 8,212 3 View

Interested to stain mice tissue with WGA 488 conjugate, anybody has a protocol to recommend?

Interested to stain mice brain tissue with WGA 488 conjugate, appreciate if anyone willing to offer me some guidance or suggestions! Thank you!

28 February 2021 3,951 2 View

Any specific pipeline or parameter to analyse total transcriptomics study of brain tissue samples?

I have two groups of brain samples, control and treated for example. It was total RNA nova seq sequencing. I tried all the available pipeline like: star+rsem+deseq2, Hista+stringtie+cuffdiff,...

27 February 2021 356 6 View

B-mercaptoethanol (BME) protocol?

Hi everybody, I have been running a multiplex IHC which allow me to stain the same tissue with different markers (Primary Ab + Secondary conjugated Ab) (AF487, AF555, AF647). Since I would like to...

27 February 2021 5,028 2 View

Is there anyone who experienced with cytotoxic effect of Hoescht 33342 dye?

Is Hoechst toxic to cells? In general, it is known as non-toxic. I am working with dsRED MDA-MB-231 cell line. I applied it for my PDMS-based microfluidic platform, for this reason, I incubated...

26 February 2021 9,119 3 View