Dear Sir. Concerning your issue about the synthetic ligands are available for the enzyme Kynureninase. The endocannabinoid system comprises of the endogenous ligands called endocannabinoids, the enzymes which synthesize and degrade them and the receptors, to which these ligands bind. Two types of cannabinoid receptors have been cloned so far, the type 1 and type 2 cannabinoid receptor (CB1 and CB2) from rat cerebral cortex and human promyelocytic leukaemia cells, respectively. They are class A GPCRs and belong to the Gi/o-coupled GPCR superfamily and they couple to Gi/o type inhibitory G-protein, thus their activation inhibits cyclic adenosine monophosphate (cAMP) production and stimulates mitogen-activated protein kinases (MAP). I think the following below links may help you in your analysis:

https://www.tocris.com/products/l-kynurenine_4393 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929320/pdf/nihms550947.pdf

Thanks