This is not really a direct answer to your question, and for gene expression analysis I would look at both you may find some interesting differences?? However, if you are looking a function, and are prepared to consider an avant garde theory? I think you will find this paper on the orchestration of DNA repair I published in the journal Theory in Biosciences on 01/01/2022 of interest. It actually concerns much more than DNA repair, but more evidence existed in the literature for this topic at the time of writing.
https://www.researchgate.net/publication/357484839_Is_DNA_repair_controlled_by_a_biological_logic_circuit
I presented more on this work in Boston Ma. in April at the Cell and Experimental Biology meeting, this Powerpoint gives the wider biological implications of this type of regulation in rapid (sub second) decision making.
https://www.researchgate.net/profile/Philip-Penketh/publication/360149650_Phosphologic_in_DNA_repair_and_rapid_cellular_data_processing_CEB-2022/links/626982d905d79a3968a5fcb9/Phosphologic-in-DNA-repair-and-rapid-cellular-data-processing-CEB-2022.pdf?_sg%5B0%5D=6NRY4XF6eiV1irthYkGC06IExxt5Kx6MriH1RXc0EUwqQ-Cq9364cIlm8ac6VdhWsoPrm07Nrw92k1L9-wLJHA.04pzWPOBeElef7ehL9kFBPJeprlyMqDEe_vdhBx-AJA2Vo8OzY9xsIPNDIXUfv5TJ6XOaPES-D1XR6xRrDU6nw&_sg%5B1%5D=dJEQkjAjPiPS2jIBuFfzQDtbHYhN9HeVq6pvV-ZbZK7l7OFAkZzmZQslPKCbewYp_Qn5h49Dr3k6STW4BN9-K-yCm-LCKzgYjO3XNgysBSes.04pzWPOBeElef7ehL9kFBPJeprlyMqDEe_vdhBx-AJA2Vo8OzY9xsIPNDIXUfv5TJ6XOaPES-D1XR6xRrDU6nw&_iepl=
All the best, Phil
You need whole protein to analyze gene expression. How is just one unit help in studying the expression, when you never know how many regulatory sites might be present in the other half.
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