Modelling liver cancer has always been difficult for various reasons. However there are plenty of models available which develop liver carcinoma. But finding an ideal one for a particular study could be a real challenge.
Will depend much on what you want to do. Are you locked into mouse? If not, I would consider rat - there is a abundnace of work published. Esay to induce lver cancer e.g. with nitrosamines (orally), and there is a very nice detailed dvelopment from early preneoplastic lesiond (some of wcich are revesible) through more advanced lesions to fully malignant tumors.
See for example Ittrich et al:
Article Prevalidation of a Rat Liver Foci Bioassay (RLFB) Based on R...
Agree with Enzmann Sir... but its 2 depends on ur budget. otherwise its not a big issue u choose Swiss albino mice (Mus musculus) also. Easy to induce liver cancer.. hepatic carcinoma by nitrosamines family....a potent environmental carcinogen family.
Thank you for all the suggestions.
I wish to rephrase my question as follows:
Which kind of models have been proven to resemble the gene expression patterns and histology of the human disease?
Our focus remains to be able to identify and validate novel biomarkers.
Any suggestion as to the best manner to image non invasively DEN-induced liver cancer in mice ?
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