Best approach to identify/prioritizing SNPs mediating a significant genetic correlation? What about genes/pathways/functions?

I am reporting some cross-phenotype genetic correlations (LDSC method) that are statistically significant after multiple test correction. Peer reviewers have asked us to report top SNPs that might...

31 December 2017 2,939 4 View

Do family-design and case-control GWASs arrive at the same answers? Any papers discussing actual/theoretical comparability or divergence?

02 March 2017 1,216 1 View

Any publications examining transcriptome (postmortem brain or blood, RNAseq or microarray) of ID/DD vs typical development?

02 March 2017 8,054 0 View

Is there a central database where one can look up CNVs in order to get a sense of evidence whether they might be pathogenic/affect brain development?

05 June 2016 944 2 View

Which staining approach is best (Golgi or alternative?) with pre-sectioned (40 microns) dendritic morphology/spine studies in fixed mouse brain ?

03 April 2015 5,076 6 View

Does ambient proton concentration (pH) alter the behavior of ROS/RNS?

02 March 2015 6,798 12 View

Has transcriptome-wide expression research ever translated into a clinically used biomarker or tool?

01 February 2015 2,145 6 View

Is there a tissue repository for post-mortem brain tissues obtained from subjects with post-traumatic stress disorder (PTSD)?

I'm wondering whether anyone is aware of a tissue repository where researchers can apply for access to post-mortem brain tissues obtained from subjects with post-traumatic stress disorder (PTSD)?...

08 September 2014 6,958 3 View

Any recommendations for a feature selection method that can be applied the same way across multiple kernel types (linear, radial, polynomial)?

Background: I have been working with SVM classifiers of microarray data for about 2 years. After a week-long search of the literature, I'm only beginning to appreciate the complexity of selecting...

05 June 2014 2,271 6 View

How can I measure MMP-1 protein activity or protein level from liver tissue?

Instead of checking only the mRNA level, I want to check the active protein level of MMP-1 in Liver tissue from mice. How can I do that?

03 March 2021 1,763 2 View

Anyone plz suggest relevant topic for research in image processing+Deep learning.?

I have selected brain tumor images ...but now found that already lots of research done n this topic.

03 March 2021 5,774 3 View

Does any one know how i can prepare liver tissue with transmission electron microscope with good fixation?

i have problem in preparation of liver tissue with bad cell organelles and how i can adjust osmolarity

03 March 2021 8,890 1 View

New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before?

Question to you and THEM, the New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before? There appears to be a core problem for...

02 March 2021 3,024 2 View

How does one access the Cranet survey data on HRM practices?

Hello, The Cranet website does not provide any lead to the data obtained from their multinational survey on HRM practices. Any help on accessing the data would be most appreciated. Thank...

01 March 2021 9,536 3 View

Is there any research regarding how training and development is going to change in the era of Fourth Industrial Revolution?

As the organizations getting prepared for the fourth industrial revolution, to enhance the skills of their workforce what type of changes are necessary and going to occur in the training and...

01 March 2021 3,199 3 View

What kind of food stuff increase the potentiality of human brain?

There are different kinds of food stuffs which we intake daily according to our requirements. Carbohydrate, protein, fat, mineral, vitamin, water are mainly working for the growth and development...

01 March 2021 831 2 View

Interested to stain mice tissue with WGA 488 conjugate, anybody has a protocol to recommend?

Interested to stain mice brain tissue with WGA 488 conjugate, appreciate if anyone willing to offer me some guidance or suggestions! Thank you!

28 February 2021 3,951 2 View

Any specific pipeline or parameter to analyse total transcriptomics study of brain tissue samples?

I have two groups of brain samples, control and treated for example. It was total RNA nova seq sequencing. I tried all the available pipeline like: star+rsem+deseq2, Hista+stringtie+cuffdiff,...

27 February 2021 356 6 View

B-mercaptoethanol (BME) protocol?

Hi everybody, I have been running a multiplex IHC which allow me to stain the same tissue with different markers (Primary Ab + Secondary conjugated Ab) (AF487, AF555, AF647). Since I would like to...

27 February 2021 5,028 2 View