I'm wondering if any generalization or educated guess can be made about vascular surface area per unit of cubic human brain tissue. Would the white matter or the grey matter have a larger "vascularization quotient" ?
I am reporting some cross-phenotype genetic correlations (LDSC method) that are statistically significant after multiple test correction. Peer reviewers have asked us to report top SNPs that might...
31 December 2017 3,081 4 View
Many transcriptome (genome-wide expression) studies have been carried out examining autism vs typical development using microarray or RNAseq in postmortem brain or ex-vivo blood. I know they...
02 March 2017 8,150 0 View
I happen to be thinking about autism and other disorders with considerable SNP heritability. I'm curious to hear people's thoughts. Mine are below: One might assume the affected cases are...
02 March 2017 1,336 1 View
Not an expert on CNVs. I have a few samples from children with autism and their typically-developing siblings, which contain a few previously identified CNVs. Would like to get a sense if these...
05 June 2016 1,091 2 View
I'll preface this post by indicating that I work primarily in bioinformatics, but I need to demonstrate some wet-lab skills in order to graduate with a degree in neuroscience. I'm proposing a...
03 April 2015 5,219 6 View
Let me preface this by saying I am not a biochemist. My logic may be very incorrect, but I'm looking for some guidance from someone who has a much stronger grasp on this field. Or if anyone...
02 March 2015 6,892 12 View
This is a big picture question for research historians among us. I'm wondering whether any gene expression microarray or RNA-seq study (or series of studies) has identified anything (a biomarker...
01 February 2015 2,240 6 View
I'm wondering whether anyone is aware of a tissue repository where researchers can apply for access to post-mortem brain tissues obtained from subjects with post-traumatic stress disorder (PTSD)?...
08 September 2014 7,041 3 View
Background: I have been working with SVM classifiers of microarray data for about 2 years. After a week-long search of the literature, I'm only beginning to appreciate the complexity of selecting...
05 June 2014 2,377 6 View
Hello everyone, I have recently started using the microtome device for sectioning of paraffin-embedded mice lung. While I had some success in sectioning and observing proper ribbons, some of my...
06 August 2024 666 4 View
Brain and body mass together are positively correlated with lifespan (Hofman 1993). The duration of neural development is one of the best predictors of brain size, and conception is the best...
05 August 2024 6,247 3 View
Hi everyone, I am working on brain slices for visualizing a protein in the soma and dendrites, using a fluorescence tag. However, I need a tool (not paid) for reconstruction of the whole neuron,...
04 August 2024 4,725 2 View
I will be with my students collecting seaweed samples in a marine farm and later we will process this tissue for RNA isolation and further sequencing. Does anyone have tips on how to collect the...
04 August 2024 501 2 View
I´ve been unable to find specific information about this neurotrophin in the CNS of rabbits exclusively. There is extensive info in mice, fish and rats, but in brain´s rabbit is hard to find....
04 August 2024 762 1 View
Do You Know Untreated TMJ Affects Your Brain And Entire Body?
04 August 2024 6,282 1 View
TEP presentation caption (The Environmental Project) Re: Why should Washington’s DC, or any country government point of location think of as nowadays of as to being 'tomorrow as to come! if it...
03 August 2024 2,484 1 View
I heard an explanation about something being a better proton acceptor or lone pair donor but that doesn't make sense. I couldn't explain in in terms of acid-base theory. The hand-waving way I saw...
03 August 2024 9,918 0 View
On a personal note, even though technology has attracted a lot of interest and funding to combat climate change, it is becoming more and more clear that taking care of the "Human Dimension" is...
02 August 2024 6,773 12 View
All plants are green but some of these plants becomes yellow. I did not found any reason. Please help me to find out the real problem.
01 August 2024 589 4 View