There is a lot of research on using exosomes in nanoplasmonic sensors but could we use microRNA instead and whether the sensitivity would increase or decrease??
Besides, it is actually a tricky question. Cancer cells release multiple types of vesicles including exosomes, oncosomes, large ocosomes, sometimes migrasomes and so on. So defining which one would be the best marker is complicated. Besides you question depends on which fluid you are working with and which cancer. Concerning microRNAs, it is again tricky because microRNAs can be loaded into exosome or others versicles or free in the blood circulation, therefore any study comparing exosomes to microRNAs to know which would be the best is flawed by definition. I would rather look, in your cancer model, if there is any data showing that one of the two entities correlates a lot with the cancer development and go with it.
I found this that looks interesting : Article Nanoplasmonic sensors for detecting circulating cancer biomarkers