Dear Koushik Manna, there are many studies available on this matter, where long term exposure and accumulation of AG NPs manifest according to the first reference via three mechanisms. Please find extended details in the following documents. My Regards
@ Kaushik, the adverse effect of silver nanoparticles mainly on oxidative stress, DNA damage and cytokine induction. It may be absorbed through the lungs, intestine, and through the skin into circulation and may reach organs like liver, kidney, spleen, brain, heart and testes. It may also cause mild eyes and skin irritations. It can also act as a mild skin allergen.