The key properties of a stem cell were first defined by Ernest McCulloch and James Till in the early 1960s. They discovered the blood-forming stem cell, the hematopoietic stem cell (HSC), through their pioneering work in mice. McCulloch and Till began a series of experiments in which bone marrow cells were injected into irradiated mice. They observed lumps in the spleens of the mice that were linearly proportional to the number of bone marrow cells injected. They hypothesized that each lump (colony) was a clone arising from a single marrow cell (stem cell). In subsequent work, McCulloch and Till, joined by graduate student Andy Becker and senior scientist Lou Siminovitch, confirmed that each lump did in fact arise from a single cell. Their results were published in Nature in 1963. In that same year, Siminovitch was a lead investigator for studies that found colony-forming cells were capable of self-renewal, which is a key defining property of stem cells that Till and McCulloch had theorized.[1]
In 1981, embryonic stem (ES) cells were first isolated and successfully cultured using mouse blastocysts by British biologists Martin Evans and Matthew Kaufman. This allowed the formation of murine genetic models, a system in which the genes of mice are deleted or altered in order to study their function in pathology. By 1998, embryonic stem cells were first isolated by American biologist James Thomson, which made it possible to have new transplantation methods or various cell types for testing new treatments. In 2007, Shinya Yamanaka’s team in Kyoto, Japan converted fibroblasts into pluripotent stem cells by modifying the expression of only four genes. The feat represents the origin of induced pluripotent stem cells, known as iPS cells.[2]
In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations.
In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations.
Stem cells are unspecialized cells of the human body. They are able to differentiate into any cell of an organism and have the ability of self-renewal.
These cells are widely used to solve many problems and diseases, most notably
Joints erode.
Sports injuries cases. Sclerosis.
Chronic skin ulcers, especially those caused by diabetes
Burn treatment.
Scleroderma.
Used in cosmetology
It is also used with the goal of slowing aging processes.
It is used to stimulate surgical procedures, especially in cases of mastectomy.
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use.
Stem Cells Applications in Regenerative Medicine and Disease Therapeutics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969512/
Stem cells: past, present, and future | Stem Cell Research & Therapy | Full Text
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1165-5
A bone marrow transplant (BMT), also called a stem cell transplant, is a procedure in which diseased or damaged bone marrow cells are replaced with healthy ones. This procedure is performed after a patient has high-dose chemotherapy or radiation. Conditions successfully treated with BMT include cancers, such as leukemia, lymphoma, multiple myeloma and solid tumors, as well as aplastic anemia.
Autologus BMT : Auto means self. Stem cells are removed from the patient before the high dose chemotherapy is given. After the chemotherapy, stem cells are given back intravenously.
Allogenic BMT : Stem cells are obtained from the donor. The donor must have the same genetic makeup as the patient. Generally the brother or sister of the patient is most likely to be a good match. Special blood tests are done to determine if a donor is a good match.
Umblical Cord Transplant : Stem cells removed from the umbilical cord immediately after the birth of the baby. It will be stored and used as and when it is needed.
Stem cells are not specialized cells of the human body which are utilize to manipulation of much disease .
Modern applications of stem cells are an attempt to treat some chronic diseases, for example, type 1 diabetes by changing beta cells of the pancreas and trying to use stem cells to treat some types of cancer.
please read this link
https://www.scientificamerican.com/arabic/articles/news/stem-cell-therapy-is-still-under-investigation/
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use
good answer all Terry Purvis
Rasha Adnan ahmed Ali Mohamed Rasheed Ali Alwaeli Shakir Tuleab
Cells in the body have specific purposes, but stem cells are cells that do not yet have a specific role and can become almost any cell that is required.
Hello
The term ‘stem cells’ is used to describe primitive unspecialized cells that are capable of self-renewal, show a high potential for proliferation, and can differentiate into multi-linear specialized cells. Stem cell therapy has strongly developed since the 2010s to date. Besides hematopoietic stem cell transplantation, mesenchymal stem cell (MSC) transplantation becomes a new choice for regenerative medicine. These initial results from clinical trials of MSC transplantation showed that MSC transplantation is opening a new revolution of stem cell therapy in next decades. Embryonic stem cells as well as pluripotent stem cells have vastpotential for treatment, but they only could become treatment options when the problems about in vivo; in vitro spntaneous differentiation and tumorigenesis in vivo would be strictly controlled. In conclusion, stem cell therapy is continously growing at a high rate, it truly becomes an essential treatment in modern medicine.
Ref : http://www.bmrat.org/index.php/BMRAT/article/view/79
Good Luck
This cell is characteristic by renewal.. It's have multipotiential. Most its applected in Medical such as genetic diseases
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1165-5
