I have two treatments:1, breast cancer patients treated with drug A. 2, Breast cancer patients treated with Drug A+B. Each patient is either sensitive or resistant to drug A or Drug A+B. That means I have four groups in all. I want to extract the differential genes that related with drug B. My hepothesis is: if a patients is sensitive to Drug A but resistant to Drug A+B, then Drug B is the reason that cause the resistant. And if Drug A is resistant to Drug A+B, but sensitive to Drug B, then Drug B is the reason that cause sensisive. My quesion is how to design the compare matirx? what kind of statistic method should I use? thanks in advance!
Dear Yongzi
I am not sure that your conclusions can be accepted without further experiments.
For example,
do cells express MDR proteins,
or the drugs are weak bases that can be easily ionized
or what chemical interactions occur between the drugs.
Answering these questions should precede the statistical representation.
Kind regards.
Tomas
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