What should be the gold standard for measuring infectivity in Prion diseases since many researchers are of the opinion high level of PrPSc is not?

Joshua Adekunle Babalola @Joshua-Babalola-4

19 April 2016 1 9K Report

High deposition of the disease causing isoform PrPSc is thought to be a measure of infectivity in Prion diseases but many researchers are now of the opinion it isn't.

S. Béatrice Marianne Ewalds-Kvist

Dear Joshua,

consult the authors to these papers:

Article PRION CHARACTERIZATION USING CELL BASED APPROACHES

Article PrP Expression Level and Sensitivity to Prion Infection

Article Measuring cytokine profiles longitudinally during prion infection

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Science method

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