I am a fresh man in cell molecular biology. I was studying the liver metabolites function and the inflammatory response with exogenous toxicant. I knew the hepatocyte is the metabolite center for human body. It could synthesize a lot of enzymes, albumin and metabolize toxicant. But I was confused whether the hepatocyte could secrete the pro-inflammatory factor, such as TNF-α, iL-6, when liver or hepatocyte was treated with anti-cancer drug doxorubicin (DOX), and exogenous porphyromonas gingivalis. I saw two papers. They reported the upregulation of mRNA in these treatment.
[1] Zhang W, Yu J, Dong Q, et al. A mutually beneficial relationship between hepatocytes and cardiomyocytes mitigates doxorubicin-induced toxicity[J]. Toxicology letters, 2014, 227(3): 157-163.
[2]Takano M, Sugano N, Mochizuki S, et al. Hepatocytes produce tumor necrosis factor‐α and interleukin‐6 in response to Porphyromonas gingivalis[J]. Journal of periodontal research, 2012, 47(1): 89-94.
Most of other materials reported that the immune cells and adipose tissue was involved the secretion of these pro-inflammatory factor. It seems the function the hepatocyte only working on the metabolites, enzyme synthesis, and energy storage.
Thank you very much!
Proinflammatory cytokine production/secretion is not one of the main functions of hepatocytes. However, like many other cell types, hepatocytes do produce some proinflammatory mediators under stress conditions, such as IL-6, IL-22, IL-1β and TNF-α. Please refer to the following article for more details: https://www.nature.com/articles/cmi201597.
Check this paper: https://www.physiology.org/doi/abs/10.1152/ajpgi.1997.273.2.G322?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
Thank you for helping me. If the hepatocyte secrete these cytokines, will these cytokines affect other tissue cells?
Surely, yes. However, exact influence depends on many factors. Too complex to answer in few words. Sorry
Secretion of proinflammatory cytokines is a way for cells to communicate with one another in case of "danger". In that sense, secretion of cytokines by hepatocytes will certainly affect other tissue cells. But what other cell types are affected and how these cells are affected need more studies to answer.
Thank you very much! So, it is better to connect the toxicity testing with drug metabolism testing, mRNA analysis and immunostaining to see the cytokines communication.
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