DAMPs activate various inflammasomes to induce the production of proinflammatory cytokines. Therefore, it is practical to assess their functional ability to activate the inflammasome activity using a well-characterized cell model such as PMA-differentiated THP-1 cells. However, other approaches can be used.
DAMP is not a single molecule but a collection of damage associated molecule patterns, that activate a number of NOD-like receptors that include NOD1,2 NLRp3-inflammasome to name a few. So you need to know what kind of DAMP molecule you are dealing with, usually they are HMGB1, HSP60, 20.
To answer your question you need to give some more specific information.