Hi Rachel

The platin induced toxicity is similar in both the ears and the kidneys and most often they develop simultaneously. We run a pharmacotherapy induced ototoxic clinic and what we often see is high frequency hearing loss with a reduction in the GFR.

Does this help?

This is my second attempt at posting. I apologize for the duplicate answer.

Hi Rachel,

First, are you defining ototoxicity as hearing loss, tinnitus, or both? In my experience, iv cisplatin exposure in humans can induce changes both in hearing and kidney function simultaneously, successively (in no temporal order) and independently. Head and neck radiation might exacerbate the hearing loss effect.

Natalie, are your results showing simultaneous degradation published? I would be very interested in reading about your findings. Also, what frequency range are you referring to when you say high-frequency?

Thanks!

Hi Kelly, the clinic has been running for one year now. We are in the process of publishing preliminary results. The high frequency hearing loss that we can measure starts with a downward slope at 8000 Hz in both ears.

THANK YOU!

Hi Natalie and Rachel,

What is the time course i.e. number of days after administration of cisplatin that you see ototoxicity or decreased GFR? I am specifically interested in effects after first dose if you happen to know.

Thanks,

Shveta