I am planing to work on the yield optimization of natural products.
While doing a literature survey, I came across the Placket and Burman Plot and Response Surface Methodology.
Now I am damn confused between the two of them.
What is the difference between Complex Composite Design (CCD) and Box Benkhen Design (BBD)?
And how to decide whether we have to apply CCD or BBD??
Kindly help.
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Plackett-Burman is a fractional factorial design based on main effects alone. It is a two level screening design that is used to identify significant factors that influence response when the number of factors is greater than 5.
Response surface methodology is the followup of Plackett-Burman or sometimes can be used standalone. It is full factorial design based on main, interaction and quadratic effects. It is three or five level design that is used to optimize significant factors identified by Plackett-Burman method.
There are two designs in response surface methodology - central composite design (CCD) and Box-Behnken design (BBD). Sometimes, CCD doesn't work well for biological systems whereas BBD works well for all the systems.
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You can see that paper to explain RSD
https://www.researchgate.net/publication/308357814_Optimization_of_Ficus_deltoidea_Using_Ultrasound-Assisted_Extraction_by_Box-Behnken_Statistical_Design
Article Optimization of Ficus deltoidea Using Ultrasound-Assisted Ex...
Placket burman design is just the secreening design which screen the component while Response surface design like CCD and BBD are the level optmization design. SO if you have already selected variables/componentsthan directly go for CCD, dont waste time on plackett Burman design.
Any query in this regards, plz do contact me on: [email protected] (M); +91 9714758199
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