We wish to prepare chitosan nanoparticles of a class IV drug. What molecular weight of chitosan should I use to get considerable size and encapsulation. Also advice on deacetylation degree.
This has not a real answer... depends on so many things such as the desirable size, the pH stability of your drug, the route of administration, the type of nanoparticles and the process to produce them. Furthermore, the degree of acetylation will also influence the final zeta potential on your particles, do you intend to inject those?
Dear Gustavo,
We are aiming it for for oral route. My drug is stable enough in varied pH conditions and the size expectation is 100-200 nm. Method would be ionic gelation. Kindly suggest what type of chitosan can be used in this case.
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